Article 12220

Title of the article

MORPHOMETRIC PULMONIC INDICATORS USING MEXIDOL IN RATS WITH EXPERIMENTAL ACUTE RESPIRATORY DISTRESS SYNDROME 

Authors

Makiev Georgiy Georgievich, Student, North Ossetian State Medical Academy (40 Pushkinskaya street, Vladikavkaz, Russia), E-mail: allagurina@yandex.ru
Gurina Alla Evgenievna, Candidate of medical sciences, associate professor, sub-department of biological chemistry, North Ossetian State Medical Academy (40 Pushkinskaya street, Vladikavkaz, Russia), E-mail: allagurina@yandex.ru
Gabolaeva Nadezhda Aslanbekovna, Assistant, sub-department of biological chemistry, North Ossetian State Medical Academy (40 Pushkinskaya street, Vladikavkaz, Russia), E-mail: allagurina@yandex.ru
Sokolovskiy Nikolay Valer'evich, Candidate of medical sciences, associate professor, sub-department of pathological anatomy with forensic medicine, North Ossetian State Medical Academy (40 Pushkinskaya street, Vladikavkaz, Russia), E-mail: allagurina@yandex.ru 

Index UDK

616-008.3/.5+ 616.24-005.98 

DOI

10.21685/2072-3032-2020-2-12 

Abstract

Background. The purpose of this work is to evaluate the effectiveness of Mexidol on the degree of development of acute respiratory distress syndrome (ARDS) by morphometric parameters of lung tissue.
Matherials and Methods. The study was conducted on 30 rats of the Wistar line: I gr. – control, II gr. – with ARDS, modeled by in / b administration of 0.1 % solution of epinephrine at a dose of 15 mg / kg, III-with in / b administration of Mexidol at a dose of 400 mg/kg and further creation of ARDS. In all groups, visual lung assessment, morphohistological examination of lung tissue and morphometric analysis were performed in the "Olympus DP Soft" program with two-factor dispersion analysis.
Results. In ARDS, there is diffuse damage to the alveoli, some of them in a dormant state. When Mexidol is corrected, there is a significant decrease in the parameter of interstitial edema, intraalveolar edema, fullness of microvessels, and an increase in the parameter of unchanged parenchyma compared to the group of rats without drug administration.
Conclusions. Administration of Mexidol to rats with ARDS leads to a significant decrease in morphometric parameters characterizing pulmonary edema. 

Key words

acute respiratory distress syndrome, mexidol, epinephrine, morphometric indicators, pulmonary edema, plethora 

Download PDF
References

1. Kassil' V. L. Klinicheskaya onkogematologiya [Clinical oncohematology]. 2011, no. 4 (1), p. 54. [In Russian]
2. Fan E., Brodie D., Slutsky A. S. JAMA. 2018, vol. 319, no. 7, pp. 698–706.
3. Ranieri V. M., Rubenfeld G. D., Thompson B. T., Ferguson N. D. Journal of the American Medical Association, Am. Med. Ass. 2012, vol. 307 (23), pp. 2526–2533. DOI 10.1001/jama.2012.5669.
4. Gritsay A. I., Kolesnichenko A. P., Vlasenko A. V. et al. Federatsiya anesteziologov i reanimatologov. X s"ezd anesteziologov i reanimatologov [Federation of Anesthesiologists and Resuscitators. X congress of anesthesiologists and resuscitators]. Krasnoyarsk, 2013, p. 22. [In Russian]
5. Makiev G. G., Gurina A. E., Gabolaeva N. A. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii [Issues of biological, medical and pharmaceutical chemistry]. 2018, vol. 21, no. 8, pp. 52–57. [In Russian]
6. Gritsay A. I., Yaroshetskiy A. I. Diagnostika i intensivnaya terapiya ostrogo respiratornogo listress-sindroma [Diagnosis and intensive care of acute respiratory listress syndrome]. Moscow, 2015, p. 38. [In Russian]
7. Kulikov O. A., Khasan I. A. M., Ageev V. P., Dolgacheva I. S., Marochkina E. E. Zhurnal nauchnykh statey Zdorov'e i obrazovanie v XXI veke [Journal of scientific articles “Health and Education in the XXI Century”]. 2016, vol. 18, no. 2, p. 580. [In Russian]
8. Korzhevskiy V. E., Giliarov A. V. Osnovy gistologicheskoy tekhniki [Basics of histological technique]. Saint-Petersburg: Izd-vo SpetsLit, 2010, 95 p. [In Russian]

 

Дата создания: 23.06.2020 08:49
Дата обновления: 29.06.2020 13:58